Periodontitis is a chronic infectious disease. With its incidence as high as 47%–68.97%, studies show that this is the leading cause of tooth loss in adults. Periodontitis affects function, oral health, and aesthetics and has severe relations to endocrine disturbance, e.g., diabetes mellitus, obesity, osteoporosis, and some cardiovascular disease. Aggressive periodontitis is characterized by early-onset familial aggregation
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